The systemic anti-cancer drugs

The aim of chemotherapy is to work systematically to eradicate occult metastases and residual tumor cells.

The current trend is the administration of cycles of chemotherapy, which is an association of more antiproliferative drugs: association of cyclophosphamide, methotrexate, 5-fluouracile (CMF), that of adriamycin, cyclophosphamide (AC), and finally that of cyclophosphamide, doxorubicin, and 5-fluorouracil (CAF).

The choice of the association depends on the size of the tumor, the metastatic involvement of lymph nodes, the presence of oncogenic hormone receptors expression.

The term "neoadjuvant" refers to the use of preoperative cytotoxic drugs. This type of treatment is indicated when the tumor is large and technically unresectable: chemotherapy can make to significantly decrease the volume until it is operable.